Since 2005, Dr Niclou runs the NORLUX Neuro-Oncology Laboratory at the Luxembourg Institute of Health (www.lih.lu), with the aim to develop novel treatment options for malignant brain tumor patients (https://norlux.lih.lu/). Her research focus is glioma invasion, tumour plasticity and metabolism. Her group established relevant pre-clinical glioma models, including patient-based 3D tumor organoids and orthotopic xenografts (PDOX).

In May 2019, Dr Niclou was appointed director of the department of oncology at the Luxembourg Institute of Health, overseeing 11 research teams in fundamental and translational cancer research. Since 2014, Dr Niclou is adjunct professor at the University of Bergen in Norway. She serves on the executive board of the European Association for Neuro-Oncology (EANO) and on the scientific advisory board of the CNS section of ESMO. She also serves on the editorial board of Neuro-Oncology, the main journal of the neuro-oncology community and is associate editor of the sister journal Neuro-Oncology Advances.