Professor Gary Middleton

Professor of Medical Oncology, University of Birmingham

Professor Gary Middleton is a Medical Oncologist who specialises in lung cancer and colorectal cancer. He has many years of experience in patient treatment, and also in development of novel clinical trials. Appointed to a chair of Medical Oncology at Birmingham in 2013, he has built up a strong clinical and translational research programme. Gary also serves as a Clinical Director for the CRUK Birmingham Centre, Director of the Birmingham ECMC and is Lead for the Birmingham CRUK Clinical Academic Training Programme.

A key interest is in stratified approaches to patient treatment, and Gary has a strong presence in UK stratified medicine clinical trials. He is Chief Investigator for the National Lung Matrix Trial, a multi-centre, multi-arm, molecularly stratified clinical trial programme for UK patients with lung cancer. Outcome data was published in Nature in 2020. He is also interested in stratification approaches for immunotherapy and leads on the ANICCA trial, a phase II study in high class II expressing microsatellite stable colorectal cancer, a study directly translating the clinic work from his laboratory programme exploring the determinants and dynamics of class II expression in cancer. Another research focus is in understanding the tumour microenvironment and how this impacts on new therapeutic approaches, including novel immunotherapy strategies. One particular area of active study is myeloid derived suppressor cells (MDSC), which are thought to suppress tumour-specific immune responses. The discovery of novel predictors of checkpoint blockade toxicity is a key area of current research.

Back to Speakers


BNOS @BNOSOfficial   7:22 AM - Fri 24 Sep 2021

🔔A fantastic #NeuroOncology learning opportunity not to be missed @EANOassociation

BNOS @BNOSOfficial   8:18 PM - Mon 20 Sep 2021

RCR Learning Live 21 is The Royal College of Radiologists' annual conference, delivered digitally from Monday 4 October until Friday 22 October. On Tuesday 5th October our Vice President Prof. Susan Short will be presenting. Find our more here:

BNOS @BNOSOfficial   12:39 PM - Mon 20 Sep 2021

📢Survey: If you do any kind of pre-clinical modelling relating to neuro-oncology within your research group in the UK please complete this short survey (no more than 5 minutes) by 30th Sept 2021 and be in with a chance to win a £30 Amazon voucher 💗

BNOS @BNOSOfficial   2:10 PM - Fri 17 Sep 2021

Interested in attending a Neuro-Oncology meeting, conference, webinar or general event? Many CPD accredited & some free to attend! @The_SBNS @EANOassociation @UKBANN @BIR_News @cbtddc @NCRI_partners @theIBTA @UKONSmember @NeuroOnc @BASO_ACS @wfnos2022

BNOS @BNOSOfficial   12:09 PM - Thu 16 Sep 2021

📢An interactive workshop by @cbtddc Clinical Trial Readiness for CNS Drug Delivery!

BNOS @BNOSOfficial   12:06 PM - Thu 16 Sep 2021

📢Neuro-oncology Researchers 👀 Free webinars x 2 from @FoundationTessa & @DHSCgovuk

BNOS @BNOSOfficial   10:08 AM - Wed 15 Sep 2021

BNOS are looking for a CNS/AHP rep for Council. Please share if you can? More info here: