Professor Gary Middleton

Professor of Medical Oncology, University of Birmingham

Professor Gary Middleton is a Medical Oncologist who specialises in lung cancer and colorectal cancer. He has many years of experience in patient treatment, and also in development of novel clinical trials. Appointed to a chair of Medical Oncology at Birmingham in 2013, he has built up a strong clinical and translational research programme. Gary also serves as a Clinical Director for the CRUK Birmingham Centre, Director of the Birmingham ECMC and is Lead for the Birmingham CRUK Clinical Academic Training Programme.

A key interest is in stratified approaches to patient treatment, and Gary has a strong presence in UK stratified medicine clinical trials. He is Chief Investigator for the National Lung Matrix Trial, a multi-centre, multi-arm, molecularly stratified clinical trial programme for UK patients with lung cancer. Outcome data was published in Nature in 2020. He is also interested in stratification approaches for immunotherapy and leads on the ANICCA trial, a phase II study in high class II expressing microsatellite stable colorectal cancer, a study directly translating the clinic work from his laboratory programme exploring the determinants and dynamics of class II expression in cancer. Another research focus is in understanding the tumour microenvironment and how this impacts on new therapeutic approaches, including novel immunotherapy strategies. One particular area of active study is myeloid derived suppressor cells (MDSC), which are thought to suppress tumour-specific immune responses. The discovery of novel predictors of checkpoint blockade toxicity is a key area of current research.

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BNOS @BNOSOfficial   12:26 PM - Fri 18 Jun 2021

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BNOS @BNOSOfficial   12:29 PM - Tue 8 Jun 2021

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BNOS @BNOSOfficial   11:59 AM - Tue 1 Jun 2021

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BNOS @BNOSOfficial   4:05 PM - Wed 26 May 2021

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BNOS @BNOSOfficial   12:25 PM - Wed 26 May 2021

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BNOS @BNOSOfficial   8:49 PM - Sun 23 May 2021

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